2,4-Dichlorobenzyl alcohol

2,4-Dichlorobenzyl alcohol
IUPAC name

(2,4-Dichlorophenyl)methanol
Other names

Dybenal
Rapidosept
Myacide SP
Identifiers
CAS number 1777-82-8
PubChem 15684
ChemSpider 14918 Y
ChEBI CHEBI:48220 Y
Jmol-3D images Image 1
Image 2
Properties
Molecular formula C7H6Cl2O
Molar mass 177.03 g/mol
Melting point

57-60 °C
Boiling point

150 °C (25 mmHg)
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

2,4-Dichlorobenzyl alcohol is a mild antiseptic, able to kill bacteria and viruses associated with mouth and throat infections. It is a common ingredient in throat lozenges such as Strepsils/Gorpils. A low-pH throat lozenge containing dichlorobenzyl alcohol (1.2 mg) and amylmetacresol (600μg) has been found to inactivate Respiratory syncytial virus and SARS-Cov, but not adenovirus or rhinovirus [1]. A dentifrice containing 10% sodium benzoate and 0.3% dichlorobenzyl alcohol maintains antimicrobial activity for 5–10 minutes after brushing[2].

References

  1. ^ Oxford JS, Lambkin R, Gibb I, Balasingam S, Chan C, Catchpole A (2005). "A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV". Antiviral chemistry and chemotherapy 16 (2): 129–34. PMID 15889535. 
  2. ^ Ostergaard E (1994). "Evaluation of the antimicrobial effects of sodium benzoate and dichlorobenzyl alcohol against dental plaque microorganisms. An in vitro study.". Acta Odontol Scand. 52 (6): 335–45. doi:10.3109/00016359409029031. PMID 7887143. 
Throat preparations (R02)
Antiseptics
Acriflavinium chloride • Ambazone • Benzalkonium • Benzethonium • Cetrimonium (bromide/chloride) • Cetylpyridinium • Chlorhexidine • Chlorquinaldol • Dequalinium • Dichlorobenzyl alcohol • Hexamidine • Hexylresorcinol • Myristyl-benzalkonium • Oxyquinoline • Phenol • Povidone-iodine
Antibiotics
Local anesthetics
Other

M: RES

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noco(c, p)/cong/tumr, sysi/epon, injr

proc, drug(R1/2/3/5/6/7)